Atrial fibrillation (AF) prolongues post-operative central vascular surgery, increasing morbidity and costs. Though smaller, a few trials have shown positive results for Omega-3 fatty acids. This multi-center trial randomized 1516 patients scheduled for cardiac surgery to receive Omega 3 or placebo. Primary end point was occurrence of AF. Follow up didn’t show difference between Omega 3 and placebo (30% vs. 30,7%; P=0,74).
Conclusion: This trial does not support the use of Omega 3 fatty acids to prevent AF occurrence.
Comment: From the point of view of physiopathology, the anti inflammatory effect of Omega 3 suggested it could be useful in this context. However, though larger than previous studies, the OPERA trial does not support this hypothesis.
Roberto Marchioli
2012-11-05
Original title: Fish Oil for the Prevention of Post-Operative Atrial Fibrillation – The Omega-3 Fatty Acids for Prevention of Post-Operative Atrial Fibrillation (OPERA) .
