The main predictor of adverse outcomes (thrombosis and restenosis) after implantation of a stent is the degree of expansion according to published studies using coronary intravascular ultrasound (IVUS). It is unknown whether optical coherence tomography (OCT), in this sense, provides similar information as the IVUS. The aim of this study was to compare the degree...

The thrombotic load of culprit lesion is unidentified in the context of acute myocardial infarction that vindicates the use of thromboaspiration. This work is a substudy of TOTAL in patients underwent OCT before stenting. 214 patients randomized to thromboaspiration or only angioplasty were included. No differences between groups in plaque load, thrombus absolute volume, or...

In patients undergoing ST segment elevation myocardial infarction (STEMI) who received primary angioplasty, the strategy of manual thromboaspiration routine does not reduce the risk of cardiovascular death, recurrent infarction, or cardiogenic shock within 180 days compared with standard primary angioplasty with thromboaspiration only if necessary. This work was published simultaneously in The New England Journal...

The aim of this study was to assess treatment with the new anticoagulant Pegnivacogin and its specific antidote Anivamersen compared with bivalirudin in patients undergoing coronary angioplasty. The Pegnivacogin has an affinity for factor IXa with a longer shelf life to 24 hours and Anivamersen only has an affinity for Pegnivacogin. The combination of these...

This double-blind study included 21162 patients with a history of acute myocardial infarction randomized to ticagrelor 90 mg e/12 h, ticagrelor 60 mg e/12 h or placebo. All patients received aspirin and had additional risk factors such as age or diabetes. The history of infarction should be between one and three years before being included...

This study included 329 consecutive patients derived to coronary angiography based on myocardial perfusion tests or PET scan (positron emission tomography). The extension and severity of heart disease was assessed by angiography, and coronary flow reserve (CFR) was measured non-invasively by PET. After adjusting risk factors, ejection fraction, revascularization, etc, both the severity of angiographic...

Infarct size is an independent predictor of survival and ventricular function. Several alternatives have been tried to reduce the size of the infarcted area and its consequences. Small pilot studies suggest that inhaled nitric oxide may improve reperfusion in acute myocardial infarction with ST-segment elevation. Patients were randomized to conventional treatment versus inhalation of 80...

This multicenter, prospective, randomized trial compared the Excimer laser atherectomy (Excimer Laser Atherectomy = ELA, Spectranetics, Inc.) with a balloon angioplasty in patients with in-stent restenosis in the superficial femoral artery. The injury was greater than 4 cm and the reference vessel diameter 5 to 7 mm. The mean lesion length was 19 cm, and...

Mild refractory hypertension patients were defined as those with daytime systolic BP 135-149 and diastolic BP 90-94 mmHg in ambulatory monitoring. They were randomized to renal denervation (n = 35) versus control invasive procedure (n = 36). The primary end point was the change in systolic pressure of 24 hours ambulatory monitoring at 6 months....

This record has been created in order to evaluate the results of percutaneous aortic valve replacement in the UK and currently includes more than 4500 patients with 100% follow-up for mortality. The 3-year mortality was 61.6 % beyond the device or path. Atrial fibrillation, renal failure, chronic obstructive pulmonary disease and a EuroSCORE > 18.5...