Initial studies showed a blood pressure significant reduction to 3 years in patients with resistant hypertension, while the SIMPLICITY HTN -3 with a larger number of patients compared to a group with “Sham” procedure (renal angiography with conscious sedation) could not confirm the results. The aim of this study was to evaluate the possible confounding...
Aortic regurgitation after valve implantation has been shown to be a long -term mortality predictor. The aim of this study was to test the new Direct Flow Medical system, which is more flexible prosthesis with a lower profile that could result in minor aortic regurgitation and less need for post expansion. This multicenter study included...
TVT STS / ACC registrywas developed to obtain data from all patients undergoing percutaneous aortic valve replacement (TAVR) in the United States. The clinical outcome at 30 days was recently published (Macket al, JAMA 2013) but there are few data on the longer-term treatment that is already incorporated in clinical practice in the United States.The...
The Global SYMPLICITY registry is a prospective, multicenter study sponsored by Medtronic to evaluate long- term renal denervation safety and effectiveness in a real-world population with refractory hypertension. It plans to prospectively include a minimum of 5000 patients with refractory hypertension in 200 centers worldwide.In the 6-month analysis of the first 1000 patients included so...
There is some evidence that clonidine administered in small doses for short periods of time prior to noncardiac surgery would be able to prevent cardiac events.This study randomized 10010 patients over 45 years in 135 centers in 23 countries to clonidine or placebo. The primary end point of the study was the rate of death...
The aim of this study was to compare percutaneous aortic valve replacement (TAVR) with the self-expanding Valve Core with conventional surgery in patients at high surgical risk. Patients with a valve area < 0.8 cm2 , valvular index ≤ 0.5 cm2 , a mean gradient of > 40 mmHg or peak speeds above 4m /s...
The endoxaban is an oral direct inhibitor of factor Xa with a rapid onset of action and a half-life of 8-10 hours. Endoxaban efficacy and safety for long-term versus warfarinin patients with atrial fibrillation was not studied. This was a randomized, double-blind study that compares two different regimes of endoxaban with warfarin in 21105 patients...
Atrial fibrillation is initiated by focal triggers and maintained by an atrial substrate called fractioned complex of atrial electrograms. Isolating the pulmonary veins (triggers) through a circumferential ablation is the choice treatment in refractory atrial fibrillation but with suboptimal results. This work tested the hypothesis that don’t only isolate the pulmonary veins but also the...
Cardiovascular disease is the worldwide leading cause of death. Changes in lifestyle, diet and sedentary routine have increased risk factors. The age between 3 and 5 years is a great opportunity to intervene prospectively-effective to change lifestyle. The study was conducted in Colombia with preschool age children and intervention results were evaluated at 6-8 years...
Professor Serruys presented the results of the TROFI trial that compares the minimal intra-stent flow area in STEMI patients post primary PCI with or without manual thrombus aspiration. The minimal intra-stent flow area helps assess thrombus burden and is defined as: (stent area + incomplete stent apposition area) – (intralulminal defect area attached to the...