The HORIZONS AMI trial showed the usefulness of bivalirudin in reducing mortality and bleeding compared with the use of heparin plus glycoprotein IIBIIIA. However, some questions remained unanswered: What is the utility of starting the infusion during the ambulance journey? Is it possible to reduce the risk of acute thrombosis by extending bivalirudin infusion or<a href="https://solaci.org/en/2015/06/24/euromax-bivalirudin-during-transport-to-primary-angioplasty/" title="Read more" >...</a>

Contrast nephropathy is associated with increased morbidity and so this study evaluates the possibility of reducing the required necessary volume of contrast &nbsp;using coronary intravascular ultrasound (IVUS). Patients were randomized to IVUS &nbsp;guided angioplasty (n = 41) and angiography guided angioplasty (n = 42). IVUS-guided angioplasty requires a smaller volume of contrast (22.9 &plusmn; 12.5<a href="https://solaci.org/en/2015/06/24/mozart-ivus-reduces-contrast-volume-needed-for-angioplasty/" title="Read more" >...</a>

Currently the recommendation is 12 months of dual antiplatelet after a drug-eluting stent angioplasty. This study compared the 3 &#8211; months versus 12 months of dual antiplatelet&nbsp; after angioplasty with zotarolimus-eluting stent in real-world patients. This was a prospective, multicenter study randomized 1563 patients to receive aspirin and clopidogrel for 3 months and 1556 to<a href="https://solaci.org/en/2015/06/24/optimize-3-versus-12-months-dual-antiplatelet-therapy-after-angioplasty-with-des/" title="Read more" >...</a>

The aim of this study was to evaluate the clinical impact resistance thienopyridines through genetic analysis of CYP2C19 receptor. The primary endpoint was &nbsp;a combination of mortality, myocardial infarction, stent thrombosis in the resistance group (few responders) versus non-resistant (responders) to the thienopyridines. 1445 patients were included of which 22% were considered few responders. There<a href="https://solaci.org/en/2015/06/24/giant-evaluation-of-the-genetic-profile-of-cyp2c19-in-patients-undergoing-primary-angioplasty/" title="Read more" >...</a>

This prospective randomized study compared aggressive revascularization angiography injuries 50% versus a most conservative revascularization lesions&gt;70%.The primary end point was death, myocardial infarction and recurring revascularization. We included a total of 889 patients (449 in the aggressive revascularization group and 450 in the conservative revascularization group).No differences in major cardiac events between the two groups<a href="https://solaci.org/en/2015/06/24/smart-case-angiographic-guidanceangioplastyto-50-versus-70-lesions/" title="Read more" >...</a>

Sean Lyden 2011-08-04

The clinical benefit of thrombus aspiration during angioplasty in patients with ST-segment elevation myocardial infarction is uncertain. The purpose of this work was to test if thrombus aspiration reduces mortality. This was a multicenter, prospective, randomized and controlled study that included patients with ST-segment elevation myocardial infarction within 24 hours of evolution. The catheters used<a href="https://solaci.org/en/2015/06/24/taste-thrombus-aspiration-in-primary-angioplasty-failed-to-show-benefits-at-30-days/" title="Read more" >...</a>