drug-eluting stents

In saphenous vein graft lesions, 1st and 2nd generation DES have similar outcomes

Long-Term Outcomes with First vs. Second-Generation Drug-Eluting Stents in Saphenous Vein Graft Lesions. Nagendra R. Pokala. Catheterization and cardiovascular Intervention 2016;87:34-40 Courtesy of del Dr. Carlos Fava. Second generation DES have been proved superior to first generation DES in native arteries, but there is limited information on DES in saphenous vein grafts (SVG), from a<a href="https://solaci.org/en/2016/02/12/in-saphenous-vein-graft-lesions-1st-and-2nd-generation-des-have-similar-outcomes/" title="Read more" >...</a>

ADAPT-DES: Proton Pump Inhibitors and Clopidogrel in Patients with DES

Original Title: Proton Pump Inhibitors, Platelet Reactivity, and Cardiovascular Outcomes After Drug-Eluting Stents in Clopidogrel-Treated Patients. The ADAPT-DES Study. Some proton pump inhibitors interfere with clopidogrel metabolism and could attenuate P2Y12 reception. Prior observational and randomized studies have reported contradicting results on the clinical significance of this drug interaction. The aim of this trial was<a href="https://solaci.org/en/2015/11/23/adapt-des-proton-pump-inhibitors-and-clopidogrel-in-patients-with-des/" title="Read more" >...</a>

DANAMI3: Primary Angioplasty to culprit vessel versus multivessel guided by FFR

The aim of this study was to compare the usefulness of primary angioplasty only to culprit vessel versus complete revascularization guided by fractional flow reserve (FFR) in patients admitted pursuing an acute myocardial infarction with ST-segment elevation and have multiple injuries vessels. After a successful primary angioplasty to culprit artery, patients were randomized 1:1 to<a href="https://solaci.org/en/2015/06/24/danami3-primary-angioplasty-to-culprit-vessel-versus-multivessel-guided-by-ffr/" title="Read more" >...</a>

CULPRIT: Complete revascularization versus culprit artery of infarct only

Current guidelines suggest treating only the culprit artery of myocardial infarction with ST-segment elevation. This prospective and randomized work included 296 patients in 7 centers suffering ST-segment elevation acute myocardial infarction referred for primary angioplasty randomized to treat only the culprit artery (n = 146) versus complete revascularization (n = 150).&nbsp; In the culprit artery<a href="https://solaci.org/en/2015/06/24/culprit-complete-revascularization-versus-culprit-artery-of-infarct-only/" title="Read more" >...</a>

TITAN-AMI: Final results of bio-active coated stent

Previous studies suggest the excellent performance of the bioactive coated stent TITAN 2 compared with drug-eluting stents (DES). The aim of the study was to evaluate the results of this device in patients undergoing both ST segment elevation and without ST segment elevation acute coronary syndrome. A total of 1066 patients were included, of whom<a href="https://solaci.org/en/2015/06/24/titan-ami-final-results-of-bio-active-coated-stent/" title="Read more" >...</a>

CIBELES: Xience V comparative study vs Cypher for the treatment of total chronic occlusions.

Spanish-Portuguese multicentre CIBELES study (Raul Moreno, Madrid, Spain) compared two drug-eluting stents &#8211; an everolimus (Xience V, Abbott Vascular, USA) and a sirolimus-releasing eluting stent (Cypher Select, Cordis Corporation, Miami Lakes, Florida, USA) in the context of total chronic coronary occlusions. With a non-inferiority design, the study randomized 208 patients (1:1), using as the primary<a href="https://solaci.org/en/2015/06/24/cibeles-xience-v-comparative-study-vs-cypher-for-the-treatment-of-total-chronic-occlusions/" title="Read more" >...</a>

COMPARE II: A randomized prospective study compared the permanent polymer everolimus-eluting stent with a biodegradable polymer biolimus coated stent.

Randomized prospective study comparing the everolimus-eluting polymer-coated stent versus a biodegradable polymer with biolimus coated stent.&nbsp; While the use of first generation DES effectively reduces restenosis and reintervention rates, several meta-analyzes have shown a higher rate of late events of thrombotic origin associated with inflammatory phenomena and delayed reendothelialization at the site of implantation compared<a href="https://solaci.org/en/2015/06/24/compare-ii-a-randomized-prospective-study-compared-the-permanent-polymer-everolimus-eluting-stent-with-a-biodegradable-polymer-biolimus-coated-stent/" title="Read more" >...</a>

ISAR-DESIRE 3: A paclitaxel eluting balloon versus Taxus in the treatment of eluting stent restenosis.

Fundamentals. Background: Although we&#8217;ve had more than a decade of experience with implanting drug-eluting stents, (DES), the best treatment for restenosis on these devices remains unknown. The drug-eluting balloons are a promising alternative which avoid the possibility of a new layer of metal on the restenotic injury. This study compared the performance of these balls<a href="https://solaci.org/en/2015/06/24/isar-desire-3-a-paclitaxel-eluting-balloon-versus-taxus-in-the-treatment-of-eluting-stent-restenosis/" title="Read more" >...</a>

NEXT trial looked at a non-inferiority degradable polymer stent versus a second-generation permanent polymer stent.

Previous studies of non-inferiority (SORT-OUT III and V) compared the biodegradable polymer biolimus-eluting stent (BES) with permanent polymer stent and sirolimus-eluting stent (SES) or everolimus-eluting stent (EES), showing no differences, although the data is still contradictory. The aim of this study was to evaluate whether the recently approved BES is not inferior to EES in<a href="https://solaci.org/en/2015/06/24/next-trial-looked-at-a-non-inferiority-degradable-polymer-stent-versus-a-second-generation-permanent-polymer-stent/" title="Read more" >...</a>

DEMONSTR8: better endothelial coverage by OCT for the new DES

There is still concern about the safety of drug-eluting stents (DES) due to the possibility of late and very late thrombosis. Dual antiplatelet aggregation for a year is recommended for patients receiving DES. The objective of this study was to test the non-inferiority of a new drug-eluting stent in terms of endothelial coverage after 3<a href="https://solaci.org/en/2015/06/24/demonstr8-better-endothelial-coverage-by-oct-for-the-new-des/" title="Read more" >...</a>

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