drug-eluting stents

Best results of angioplasty with DES guided by IVUS versus angiography only

Original title:&nbsp;Intravascular Ultrasound-Guided Implantation of Drug-Eluting Stents to Improve Outcome. A Meta-Analysis.&nbsp;Reference:&nbsp;Jae-Sik Jang et al. J Am Coll Cardiol Intv 2014, epub ahead of print. Several previous studies and meta-analysis showed that implantation of conventional stents (BMS) intravascular ultrasound (IVUS) guided may decrease restenosis and clinical events. This information was not yet clear to drug-eluting<a href="https://solaci.org/en/2014/02/26/best-results-of-angioplasty-with-des-guided-by-ivus-versus-angiography-only/" title="Read more" >...</a>

The length of the stent is not an event predictor with the new generation of DES. It is the end of the Spot stenting?

Original title:&nbsp;Impact of the Stent Length on Long-Term Clinical Outcomes Following Newer-Generation Drug-Eluting Stent Implantation.&nbsp;Reference:&nbsp;Ik Jun Choi et al. Am J Cardiol 2014;113:457-464. Completely cover the lesion with a sufficiently long stent has been the preferred strategy that emerged from drug-eluting stents (DES). However, for the first-generation DES stent length has been a predictor of<a href="https://solaci.org/en/2014/02/20/the-length-of-the-stent-is-not-an-event-predictor-with-the-new-generation-of-des-it-is-the-end-of-the-spot-stenting/" title="Read more" >...</a>

Hybrid revascularization versus conventional surgery. Advantages and disadvantages for choosing ideal patients.

Original title:&nbsp;Clinical Outcomes after Hybrid Coronary Revascularization versus Coronary Artery Bypass Surgery: A Meta-Analysis of 1,190 Patients.&nbsp;Reference:&nbsp;Ralf E. Harskamp et al. American Heart Journal (2014), epub ahead of print. &nbsp; Hybrid revascularization combines long-term patency of the mammary artery connected to the left anterior descending with minimally invasive drug-eluting stents to other injuries. This in<a href="https://solaci.org/en/2014/02/18/hybrid-revascularization-versus-conventional-surgery-advantages-and-disadvantages-for-choosing-ideal-patients/" title="Read more" >...</a>

Longer follow-up registry of angioplasty in left main coronary artery. Significant differences according to the diseased segment.

Original title:&nbsp;The DELTA Registry (Drug-Eluting Stent for Left Main Coronary Artery Disease): A Multicenter registry Evaluating Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting for left Main Treatment&nbsp;Reference:&nbsp;Naganuma T, et al. J Am Coll Cardiol Intv 2013;6:1242&ndash;9 Angioplasty of the unprotected left coronary trunk has increased significantly in recent years showing good results. Currently the<a href="https://solaci.org/en/2014/01/20/longer-follow-up-registry-of-angioplasty-in-left-main-coronary-artery-significant-differences-according-to-the-diseased-segment/" title="Read more" >...</a>

Noncardiac surgery is safe after 6 months after implantation of a DES

Original title:&nbsp;Risk of major adverse cardiac events following noncardiac surgery in patients with coronary stents.&nbsp;Reference:&nbsp;Hawn MT et al. JAMA 2013;DOI:10.1001 In the patients who underwent non cardiac surgery and had coronary angioplasty with stent history &nbsp;within 2 years there was not increased in major cardiac events (MACE ) with the exception of those who were<a href="https://solaci.org/en/2013/10/11/noncardiac-surgery-is-safe-after-6-months-after-implantation-of-a-des/" title="Read more" >...</a>

Cilostazol reduces restenosis of DES in lesions larger than 40 mm.

Original title:&nbsp;Comparison of Dual Versus Triple Antiplatelet Therapy After Drug-Eluting Stent According to Stent Length (from the Pooled Analysis of DECLARE Trials).&nbsp;Reference:&nbsp;Seung-Whan Lee et al. Am J Cardiol 2013, article in press. Cilostazol, an inhibitor of phosphodiesterase III , associated with aspirin and clopidogrel showed decrease angiographic restenosis both in conventional stents as well as<a href="https://solaci.org/en/2013/10/07/cilostazol-reduces-restenosis-of-des-in-lesions-larger-than-40-mm/" title="Read more" >...</a>

Pharmacological stent intimal coverage with overlap versus no overlap

Original title:&nbsp;Tissue coverage and neointimal hyperplasia in overlap versus nonoverlap segments of drug-eluting stents 9 to 13 months after implantation: In vivo assessment with optical coherence tomography.&nbsp;Reference:&nbsp;Juan Luis Guti&eacute;rrez-Chico et al. Am Heart J 2013;166:83-94.e3. The drug-eluting stent&rsquo;s (DES) overlapping effect over neointimal healing is not completely understood. Drug overdose, large amounts of polymer and<a href="https://solaci.org/en/2013/08/05/pharmacological-stent-intimal-coverage-with-overlap-versus-no-overlap/" title="Read more" >...</a>

Hybrid revascularization, combining strengths in high-risk patients

Original title:&nbsp;One-Stop Hybrid Coronary Revascularization versus Coronary Artery Bypass Graft and Percutaneous Coronary Intervention for the Treatment of Multivessel Coronary Artery Disease: Three-Year Follow-up Results from A Single Institution.&nbsp;Reference:&nbsp;Liuzhong Shen et al. J Am Coll Cardiol Intv 2013. Article in press. Accepted Manuscript. A mammary bridge to anterior descending artery (LMCA) with a permeability &gt;<a href="https://solaci.org/en/2013/05/03/hybrid-revascularization-combining-strengths-in-high-risk-patients/" title="Read more" >...</a>

Future strategies to prevent restenosis and stent thrombosis

Original title:&nbsp;Endothelial cell repopulation after stenting determines in-stent neointima formation: effects of bare-metal vs. drug-eluting stents and genetic endothelial cell modification.&nbsp;Reference:&nbsp;Douglas G et al. European Heart Journal doi:10.1093/eurheartj/ehs240 Experimental models of vascular injury have shown that the rate of endothelial cell repopulation post-injury is a critical factor in determining subsequent neointima formation as well as<a href="https://solaci.org/en/2012/12/04/future-strategies-to-prevent-restenosis-and-stent-thrombosis/" title="Read more" >...</a>

Diabetics with multivessel, must keep waiting.

Original title:&nbsp;Strategies for Multivessel Revascularization in Patients with Diabetes. The FREEDOM Trial.&nbsp;Reference:&nbsp;Michael E. Farkouh et al. N Engl J Med 2012. DOI: 10.1056/NEJMoa1211585 This study was designed to determine the best revascularization strategy in diabetic patients with multivessel using current techniques of angioplasty (PCI) and surgery (CABG). Randomized 1:1 diabetic patients with injuries &gt; 70%<a href="https://solaci.org/en/2012/11/08/diabetics-with-multivessel-must-keep-waiting/" title="Read more" >...</a>

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