Presentation Summary: There is a clear association between hyperglycemia and the development of atherosclerosis. The GRACE sub trial, (from ORIGIN study), evaluated the administration of omega-3 and insulin glargine and their benefits in reducing atherosclerosis progression. Conducted at 32 centers in 7 countries, this study included 1,092 individuals with hyperglycemia and increased risk of cardiovascular...
Presentation Summary: ACCESS-EUROPE multicenter registry included 567 patients with severe mitral regurgitation treated with Mitral Clip in 14 European centers. Procedural success was high, (99.6%), while the 30-day mortality rate, (3.4%) and the one year rate, (18.2%) was acceptable. Annual mortality was more pronounced in those patients with a EuroSCORE greater than 20%, (76.3% vs....
Review: Stable coronary disease remains a scenario where percutaneous coronary intervention, (PCI), has not cleared the edges. In a study conducted in 28 centers in Europe and the United States, a design model was created where all patients enrolled consecutively, (all comers trial in order to avoid selection bias), received an invasive functional assessment using...
TRILOGY-ACS: Prasugrel vs. Clopidogrel in ACS without ST segment elevation in patients to be treated medically without revascularization. Read article Magnus Ohman2012-08-25
Background: Octogenarian patients represent an increasingly growing population. In addition, this age group has a higher proportion of co-morbidities with more extensive and complex coronary disease. However, they have often been excluded from major studies, whose average age is usually 60 years. Despite having a more complex coronary anatomy, the role of pharmacological stent (DES)...
Presentation Summary: The Prospective Urban Rural Epidemiologic (PURE) study evaluated 153996 people from different countries and different socioeconomic background. Tobacco consumption, physical activity and nutritional aspects were analyzed. Researchers found that meat consumption, industrialized products and saturated fat rates were more elevated in developed countries, while developing countries showed higher levels of carbohydrates consumption. Developing...
Editorial Comment: Morbimortality in diabetic patients is still a matter of deep concern in the context of reduced cardiovascular mortality of recent years. Based on the proven clinical benefit of drugs such as ACEIs or ARBs in treating patients with renal failure, the study randomized 8700 treated with aliskiren or placebo, in a 32 month...
Editorial Comment: This Phase II study included 149 patients following these criteria: NYHA II-IV heart failure, +40 yr, LVEF ≥ 45% NT-proBNP> 400 pg/ml. The study aimed at reducing NT-proBNP from baseline at 12 weeks. Results were positive; reduced left atrial size and an improvement in NYHA class were also observed. The drug was well...
Editorial Comment: Fifty per cent of all HF patients involves Diastolic Heart Failure or HF with conserved ventricular function. This study aimed at evaluating the efficacy and safety of 25mg spironolactone after a year of therapy. Results showed improved diastolic function, induced structural inverse remodelling, reduced neuroendocrine activation and reduced blood pressure (effects on cardiac...
DeFACTO: Diagnostic Precision of CT Angiography in Determining FFR. Read article James K. Min2012-08-25