Fundamentals: Etiology of cryptogenic stroke stills a major challenge for medicine. Paradoxical embolism remains one of the possible causes. Undoubtedly, adults between 20 and 54 years represent a significant proportion of this population, and this is associated with a high morbidity and high costs not only in relation to the pathology itself but also to...
Ischemic postconditioning obtained through reversible ischemia and reproduced during reperfusion after a prolonged ischemic injury has shown comparable effects to ischemic preconditioning in preclinical phase. A study in humans showed a reduction in serum markers of AMI thanks to Ischemic postconditioning in the context of primary angioplasty. Different MRI studies showed conflicting results regarding the...
Summary: Second-generation drug-eluting stents have shown better results than their predecessors. In this study we compare two second-generation drug stents in patients with unprotected left coronary trunk injuries. Methods and results: 650 patients with unprotected trunk injury were randomized to either XIENCE V (everolimus eluting) or RESOLUTE (zotarolimus eluting) stents. The primary endpoint was the...
Foreword: The EPS MGUARD stent (embolic protection stent) has a fine metal structure covered by a thin polyethylene fiber mesh with pores of 5 microns wrapping the stent that might prevent distal embolization during primary angioplasty and would therefore be particularly attractive during primary angioplasty. Methods and Results: We included 432 patients referred for primary...
Hypothermia is neuroprotective, because it reduces brain oxygen consumption in 6%, suppresses chemical reactions associated to reperfusion, reduces free radicals and mitochondrial damage. It has already been proved useful when implemented late after cardiac arrest, and its immediate use could be more beneficial. Adverse effects such as cardiac arrhythmia, infection and coagulopathy lead to abandon...
Insides : 40%-60% of patients with acute coronary syndrome with non ST elevation (ACS) are treated clinically. Prasugrel proved superior to clopidogrel in patients with ACS undergoing invasive treatment (TRITON-TIMI 38). The TRILOGY ACS randomized multicenter trial assessed prasugrel and clopidogrel in patients with ACS treated clinically. Study results were neutral and have already been...
Observational studies have shown contradicting results on the use of multivitamins. PHS II is the only randomized double blind placebo controlled trial to evaluate the long term effect of the use of multivitamins in the prevention of CVD. 14,641 physicians ≥50 were randomized in 1997 to receive placebo or an E, C and Centrum Silver...
This is an open trial that included 7 patients with ischemic cardiomyopathy and reduced the ejection fraction (between15% and 35%) administered via intra-myocardial injection with autologous cardiac derived stem cells. Security end points were major cardiac events and efficacy end point was ejection fraction (EF) improvement. At 24 weeks, one of the patients presented a...
Atrial fibrillation (AF) is a very prevalent arrhythmia and there is no known drug, device or ablation technique effective enough to treat it. Omega 3 fatty acids have electrophysiological, autonomic modulation and anti-inflammatory effects. In addition, they are well tolerated, which altogether makes them worth testing in the context of AF. 586 were randomized to...
Statins are first-line therapy for hypercholesterolemia. However, many patients are not able to achieve their goals despite the maximal dose or because of adverse effects. Monoclonal antibody RN316 binds to PCSK9 increasing LDL clearance. This trial randomized 135 patients with an average LDL of 120 mg/dl despite the maximal dose statins to receive 4 different...