DES

SYNTAX II: multiple vessels using iFR / FFR and IVUS

This study is still in progress and includes patients using SYNTAX II score based on functional invasive evaluation with iFR / FFR and performing angioplasty guided by IVUS using the biodegradable polymer everolimus eluting stent. The study seeks to prove superiority versus the first generation paclitaxel-eluting stent and non-inferiority versus surgery using historical data. We...

HYBRID: Hybrid revascularization in patients with multi-vessel

We included 200 patients (100 with hybrid revascularization and 100 with conventional surgery). The complete revascularization rate was similar between both groups (70%). Also, the event-free survival was similar with 92% for conventional surgery group and 89% for the hybrid. The revascularization of the anterior descending artery with breast bridge and angioplasty to the rest...

RIBS V: Pharmacological balloon vs second-generation drug-eluting stent in the treatment of BMS restenosis

The ideal therapy for treating in-stent restenosis continues to be debated . The pharmacological balloons showed good results in this context, but no direct comparisons available of pharmacological balloonsversus second-generation DES.This prospective, multicenter randomized 189 patients with in-stent restenosis of conventional stents receiving pharmacological balloon or everolimusDES.The primary endpoint was angiographicat 9 months spotting a...

SAFE-PCI for Women: Radial versus femoral access for women

Radial access is associated with a lower rate of vascular and bleeding complications however female patients with smaller diameter arteries such access might be technically more difficult. This prospective, randomized, multicenter study compared both approaches in the context of coronary angioplasty in female patients. 1787 patients were randomized (893 in the radial group and 894...

EUROMAX: Early and prolonged infusion of bivalirudin reduces mortality in AMI

Bivalirudin reduced mortality and bleeding compared to heparin and glycoprotein IIbIIIa in HORIZONS- AMI study. However there was a higher rate of acute stent thrombosis in patients receiving bivalirudin. This randomized study (> 90 % randomized in the ambulance) enrolled 2218 patients with ASTEMIto prolonged infusion of bivalirudin compared with heparin -associated glycoprotein inhibitors. The...

PRAMI: Treating other lesions in addition to the culprit of an acute infarction reduces events.

In the context of an ST-segment elevation myocardial infarction, primary angioplasty to treat the culprit lesion improves the prognosis. The role of angioplasty in unrelated arteries is not well established. Between 2008 and 2013, 465 patients with myocardial infarction underwent primary angioplasty and were randomized to preventive (234 patients) vs non-preventive angioplasty (231 patients). The...

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