This editorial comment was written by SOLACI.ORG and is based on an original article by Medscape which can be accessed free of charge at the bottom of this page. COURAGE patients (Patients in the Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation) who crossed from the optimal medical treatment branch to the revascularization branch within...
Original title: Impaired Cardiac Baroreflex Sensitivity Predicts Response to Renal Sympathetic Denervation in Patients with Resistant Hypertension. Reference: Christine S. Zuern et al. J Am Coll Cardiol, article in press. Renal denervation is a new treatment option for patients with resistant arterial hypertension and it is assumed to reduce efferent renal and central sympathetic activity. Given the multifactorial...
Original title: Full conversion from transfemoral to transradial approach for percutaneous coronary interventions results in a similar success rate and a rapid reduction of in-hospital cardiac and vascular major events. Reference: Vincent Dangoisse et al. EuroIntervention 2013;9:345-352. Although the transfemoral approach has clear disadvantages when it comes to bleeding complications, it continues to be the preferred approach...
Original title: Comparison of bivalirudin and radial access across a spectrum of preprocedural risk of bleeding in percutaneous coronary intervention: Analysis from the National Cardiovascular Data Registry. Reference: Baklanov DV et al. Circ Cardiovasc Interv. 2013, article in press. Bleeding complications are clearly associated to mortality increase and two of the current best strategies to reduce bleeding are...
Original title: Determinats and Outcomes of Acute transcatheter Valve-in Valve Therapy or Embolization. Reference: Raj R Makkar, et al. J Am Coll Cardiol 2013;62:418-30 Percutaneous aortic valve implantation has proven to be feasible, safe and a successful follow up. Only in a few patients is the two-valve implantation necessary due to bad positioning or embolism but...
Original title: Tissue coverage and neointimal hyperplasia in overlap versus nonoverlap segments of drug-eluting stents 9 to 13 months after implantation: In vivo assessment with optical coherence tomography. Reference: Juan Luis Gutiérrez-Chico et al. Am Heart J 2013;166:83-94.e3. The drug-eluting stent’s (DES) overlapping effect over neointimal healing is not completely understood. Drug overdose, large amounts of polymer and...
Título original: Riociguat for the Treatment of Pulmonary Arterial Hypertension. Referencia: Hossein-Ardeschir Ghofrani et al. N Engl J Med 2013;369:330-40. Many drugs have been tested for pulmonary arterial hypertension (PAH) including PDE5 inhibitors, prostanoids and endothelin receptor antagonists, however there are still missed targets in the treatment of this disease. Riociguat is a drug belonging to a...
Original title: Renal denervation in moderate treatment resistant hypertension. Reference: Christian Ott et al. J Am Coll Cardiol 2013. Article in press. Symplicity trials HTN1 and HTN 2 demonstrated that renal denervation is apparently safe in patients with severe resistant hypertension, (≥ 160 mm Hg despite ≥ 3 drugs including a diuretic). This cut of more than 160...
Original title: Pulmonary artery denervation to treat pulmonary arterial hypertension: a single center, prospective, first-in-man PADN-1 study. Reference: Shao-Liang Chen et al. J Am Coll Cardiol. Article in press. Idiopathic pulmonary hypertension is characterized by elevated mean pressure and resistance due to an imbalance between local vasodilator and vasoconstrictor added to the vascular wall renovation. Based on animal...
Original title: Percutaneous Left Atrial Appendage Suture Ligation Using the Lariat Device In Patines UIT Atrial Fibrillation Reference: Krystof Bartus, et al. J Am Coll Cardiol 2013;62:108–18. Atrial fibrillation (AF) is the most frequent arrhythmia and is associated with a 5 fold increase in stroke risk and the resulting morbimortality. Warfarin anticoagulation therapy can be effective but only...