Single chamber pacemaker implantation leads to a desynchronization of ventricular depolarization. This study aims to evaluate the implant of biventricular versus univentricular pacemaker. 902 patients were included in the group with biventricular pacemaker and 908 in the univentricular pacing group. The primary objective was to evaluate the long-term mortality and needs hospitalization for heart failure.<a href="https://solaci.org/en/2015/06/24/biopace-study-biventricular-pacing-to-prevent-cardiac-desynchronization/" title="Read more" >...</a>

The increased sympathetic activity and reduced parasympathetic tone are important pathophysiological contributors to the progression of heart failure and are associated with a worse prognosis. The aim of this study was to determine if vagus nerve stimulation is a promising strategy to modulate autonomic function, cardiac remodeling, and progression of heart failure.&nbsp; The NECTAR HF<a href="https://solaci.org/en/2015/06/24/nectar-hf-chronic-vagal-stimulation-for-heart-failure-with-low-ejection-fraction/" title="Read more" >...</a>

The MADIT -CRT study (Multicenter Automatic Defibrillator Implantation with Cardiac Resynchronization Therapy) had shown that early intervention with cardiac resynchronization therapy plus defibrillator in patients with electrical block pattern of complete left bundle branch was associated with a significant reduction of events in a mean follow-up of 2.4 years compared with the defibrillation therapy only.In<a href="https://solaci.org/en/2015/06/24/madit-crt-increased-survival-with-resynchronization-therapy-plus-defibrillator-in-patients-with-mild-heart-failure/" title="Read more" >...</a>

The aldosterone blockade has shown benefit in the treatment of heart failure with systolic dysfunction after stroke. The aim of this study was to evaluate the effect of spironolactone in patients with preserved ejection fraction. This was a multicenter, randomized study that included 1722 patients in the spironolactone group and 1723 in the placebo group.<a href="https://solaci.org/en/2015/06/24/topcat-spironolactone-in-heart-failure-with-preserved-ejection-fraction/" title="Read more" >...</a>

Editorial Comment: Fifty per cent of all HF patients involves Diastolic Heart Failure or HF with conserved ventricular function. This study aimed at evaluating the efficacy and safety of 25mg spironolactone after a year of therapy. Results showed improved diastolic function, induced structural inverse remodelling, reduced neuroendocrine activation and reduced blood pressure (effects on cardiac<a href="https://solaci.org/en/2015/06/24/aldo-dhf-aldosterone-receptor-blockade-in-diastolic-heart-failure-treatment/" title="Read more" >...</a>

Resynchronization therapy has shown benefits reducing morbidity and mortality in patients with heart failure and wide QRS. Many heart failure patients have mechanical dyssynchrony and this could be improved by resynchronization. The use of resynchronization &#8220;off label&#8221; in observational studies and small randomized studies raised up the need for a larger work to vouch this<a href="https://solaci.org/en/2015/06/24/resynchronization-therapy-is-not-beneficial-in-patients-with-heart-failure-and-narrow-qrs/" title="Read more" >...</a>