This study was designed to compare the apposition and neointimal coverage of struts by optical coherence tomography (OCT) of the new self-expanding sirolimus eluting stent (STENTYS SES) at 4 and 9 months in patients with STE-ACS. 152 patients randomized to STENTYS SES (n = 90) versus zotarolimus-eluting balloon-expandable stent (n = 62) were included. The<a href="https://solaci.org/en/2015/06/24/apposition-iv-self-expanding-des-in-acute-coronary-syndrome/" title="Read more" >...</a>
This work aimed to evaluate the use of optical coherence tomography (OCT) to guide the drug-eluting stent implantation during primary angioplasty. 201 patients experiencing STEMI to use or not OCT during primary angioplasty were randomized. The clinical and angiographic characteristics were well balanced, and no differences in MACE, cardiac death, TLR, or stent thrombosis at<a href="https://solaci.org/en/2015/06/24/robust-routinely-use-of-oct-in-primary-angioplasty-with-des-showed-no-benefit/" title="Read more" >...</a>
The use of drug-eluting stents versus bare metal stents is controversial in some clinical situations in patients at high risk of bleeding.This study randomized 1606 patients considered at low risk of restenosis but with high risk of bleeding receiving Zotarolimus eluting stent (Endeavor) or conventional stent.The clinical characteristics were similar between the two groups with<a href="https://solaci.org/en/2015/06/24/zeus-trial-patients-with-increased-risk-of-bleeding-may-benefit-from-eluting-stents-zotarolimus/" title="Read more" >...</a>
This randomized trial of a single center with consent obtained after randomization compared the use of bivalirudin versus heparin with the use of glycoprotein inhibitors arescue only in patients having ST segment elevation myocardial infarction.The primary efficacy endpoint was a composite of death, stroke, and myocardial revascularization of the target lesion and the primary safety<a href="https://solaci.org/en/2015/06/24/heat-ppci-bivalirudin-raises-major-cardiac-events-and-does-not-reduce-bleeding-the-most-controversial-and-criticized-study-at-the-acc-14/" title="Read more" >...</a>
SORT OUT V randomized trial (Odense University Hospital, Denmark) compared Nobori stent, a drug-eluting stent with biodegradable polymer eluting biolimus, versus CYPHER a drug-eluting stent with permanent polymer in the real world. Danish researchers used a non-inferiority design, by means of a primary objective of the study, the combined rate of major cardiac events (cardiac<a href="https://solaci.org/en/2015/06/24/sort-out-v-comparison-of-drug-eluting-stents-one-with-degradable-polymer-releasing-biolimus-and-the-other-a-permanent-polymer-sirolimus-stent/" title="Read more" >...</a>
Randomized prospective study comparing the everolimus-eluting polymer-coated stent versus a biodegradable polymer with biolimus coated stent. While the use of first generation DES effectively reduces restenosis and reintervention rates, several meta-analyzes have shown a higher rate of late events of thrombotic origin associated with inflammatory phenomena and delayed reendothelialization at the site of implantation compared<a href="https://solaci.org/en/2015/06/24/compare-ii-a-randomized-prospective-study-compared-the-permanent-polymer-everolimus-eluting-stent-with-a-biodegradable-polymer-biolimus-coated-stent/" title="Read more" >...</a>
Randomized trial (n = 1161 patients in 16 centers) comparing a coated stent with biodegradable biolimus polymer (Biomatrix) versus uncoated stent (Gazelle) in patients with AMI with ST segment elevation. While there is no doubt about the effectiveness of first generation SF to reduce the rate of reoperations compared with non-drug eluting stents, there is<a href="https://solaci.org/en/2015/06/24/comfortable-ami-a-randomized-trial-comparing-a-coated-stent-with-biodegradable-biolimus-polymer-biomatrix-with-an-uncoated-stent-gazelle-in-patients-with-ami-with-st-segment-elevation/" title="Read more" >...</a>
This trial is a prospective evaluation of DESolveTM bioabsorbable coronary stent implantation in a 15 patient cohort enrolled in New Zealand and Belgium. At 6 months follow up, late lumen loss was 0,19 mm, binary restenosis was 0% and thrombosis was absent. OCT evaluation showed excellent stent apposition, and 98% of evaluated struts were covered<a href="https://solaci.org/en/2015/06/24/desolve-i-fim-evaluation-of-a-fim-trial-results-of-a-bioabsorbable-stent-15-patients/" title="Read more" >...</a>
CLI-randomized study CLI-OPCI (n = 670, 1:1) evaluated the impact of stent implantation guided by angiography and optical coherence tomography (OCT), versus angioplasty guided alone by angiography. All patients who had been subjected to stent placement were then evaluated by angiography. Arm OCT, after an optimal angiographic result, an intracoronary OCT evaluation was performed. In<a href="https://solaci.org/en/2015/06/24/cli-opci-optical-coherence-tomography-oct-guided-stent-implantation-vs-conventional-angiography-guided-angioplasty/" title="Read more" >...</a>
A multicenter randomized study, (n = 573), that evaluated the role of aspirin in anticoagulated patients undergoing angioplasty. The primary endpoint was the rate of total bleeding, (TIMI), at 12 months follow-up. The administration of a dual therapy, (warfarin + clopidogrel), showed a significant reduction compared with the triple therapy, (19.5% vs. 44.9%, P <0.001).<a href="https://solaci.org/en/2015/06/24/woest-randomized-trial-that-compared-dual-therapy-versus-triple-therapy-on-anticoagulated-patients/" title="Read more" >...</a>