Background: The ADAPT-DES registry showed a strong correlation between hypo-responders to clopidogrel and the likelihood of stent thrombosis at 30 days, while the impact of aspirin response has not been evaluated so far. This presentation focuses on the aspirin response impact in the clinical course of one year. Methods and Results: A total of 8,583<a href="https://solaci.org/en/2015/06/24/adapt-des-results-at-1-year-of-the-clinical-impact-of-hypo-responders-to-aspirin-and-clopidogrel/" title="Read more" >...</a>

Summary: Second-generation drug-eluting stents have shown better results than their predecessors. In this study we compare two second-generation drug stents in patients with unprotected left coronary trunk injuries. Methods and results: 650 patients with unprotected trunk injury were randomized to either XIENCE V (everolimus eluting) or RESOLUTE (zotarolimus eluting) stents. The primary endpoint was the<a href="https://solaci.org/en/2015/06/24/isar-left-main-2-everolimus-eluting-stents-versus-zotarolimus-eluting-stents-in-the-treatment-of-the-unprotected-left-coronary-trunk/" title="Read more" >...</a>

Foreword: The EPS MGUARD stent (embolic protection stent) has a fine metal structure covered by a thin polyethylene fiber mesh with pores of 5 microns wrapping the stent that might prevent distal embolization during primary angioplasty and would therefore be particularly attractive during primary angioplasty. Methods and Results: We included 432 patients referred for primary<a href="https://solaci.org/en/2015/06/24/master-trial-prospective-multicentre-randomized-trial-evaluating-the-mguard-stent-in-the-treatment-of-patients-with-acute-myocardial-infarction-with-st-segment-elevation-stemi/" title="Read more" >...</a>

Given the individual variability of response to antiplatelet therapies, measuring platelet function and designing tailored therapies could be beneficial. The ARTIC study tested the superiority of bedside platelet function monitoring with drug adjustment vs. the conventional post DES therapy without monitoring and drug adjustment. It included 2466 patients with stable coronary disease or Non-ST Elevation<a href="https://solaci.org/en/2015/06/24/artic-study-bedside-platelet-function-monitoring-to-reduce-events-after-des-implantation/" title="Read more" >...</a>

Background: Oral antiplatelet agents have a limitation in their duration of action and bioavailability. Cangrelor is an intravenous adenosine diphosphate (ADP) inhibitor that has a powerful effect, is rapid and reversible within one hour and with the advantage of intravenous administration that reduces variability in the bioavailability of the drug. The study was designed to<a href="https://solaci.org/en/2015/06/24/champion-phoenix-cangrelor-compared-with-clopidogrel-improves-efficiency-without-increasing-bleeding-in-patients-undergoing-angioplasty/" title="Read more" >...</a>

Previous studies of non-inferiority (SORT-OUT III and V) compared the biodegradable polymer biolimus-eluting stent (BES) with permanent polymer stent and sirolimus-eluting stent (SES) or everolimus-eluting stent (EES), showing no differences, although the data is still contradictory. The aim of this study was to evaluate whether the recently approved BES is not inferior to EES in<a href="https://solaci.org/en/2015/06/24/next-trial-looked-at-a-non-inferiority-degradable-polymer-stent-versus-a-second-generation-permanent-polymer-stent/" title="Read more" >...</a>

Angioplasty of the unprotected distal left main coronary artery with 2 stents presents the less favorable results in the segment. The double kissing (DK) technique and Culotte technique have been reported as effective for the treatment of bifurcation lesions, however this has never been tested for left main coronary artery.&nbsp; The DKCRUSH-III study investigated the<a href="https://solaci.org/en/2015/06/24/dkcrush-iii-crushing-versus-culotte-technique-for-left-main-coronary-artery/" title="Read more" >...</a>

Asymmetrical expansion of the stent produces an uneven neointimal growth and increases the risk of thrombosis. The study was divided into two parts: the first one aimed at comparing, in the acute phase and the medium term, the result of provisional bifurcation stenting technique with sirolimus-eluting stent vs everolimus-eluting stent (both guided by IVUS); the<a href="https://solaci.org/en/2015/06/24/j-reverse-sirolimus-eluting-vs-everolimus-eluting-stent-in-bifurcation-lesions/" title="Read more" >...</a>

Uncovered struts compromise re-endothelization and may induce thrombosis. The new stent approved in China and already used in more than 50,000 patients, is a sirolimus-eluting device with a bio-degradable polymer. Animal studies showed rapid and complete endothelialization. The study included 20 patients with stable angina randomized on a 1:1 ratio to receive, in the same<a href="https://solaci.org/en/2015/06/24/buma-stent-new-sirolimus-eluting-stent-with-bio-degradable-polymer/" title="Read more" >...</a>

Absorbable bioplatforms are considered safe and effective in stable patients but their use in the context of acute myocardial infarction with ST segment elevation has not been reported. Low risk of heart attack with low Killip classification could be the stage for this device. 87 consecutive patients experiencing myocardial infarction with ST elevation underwent primary<a href="https://solaci.org/en/2015/06/24/prague-19-bioabsorbable-platform-for-patients-with-st-segment-elevation/" title="Read more" >...</a>