EUROMAX: Early and prolonged infusion of bivalirudin reduces mortality in AMI

Bivalirudin reduced mortality and bleeding compared to heparin and glycoprotein IIbIIIa in HORIZONS- AMI study. However there was a higher rate of acute stent thrombosis in patients receiving bivalirudin. This randomized study (> 90 % randomized in the ambulance) enrolled 2218 patients with ASTEMIto prolonged infusion of bivalirudin compared with heparin -associated glycoprotein inhibitors. The<a href="https://solaci.org/en/2015/06/24/euromax-early-and-prolonged-infusion-of-bivalirudin-reduces-mortality-in-ami/" title="Read more" >...</a>

Hokusai-VTE: Endoxaban shows solid results versus warfarin in venous thromboembolism .

The venous thromboembolism is the third most common cardiovascular disease after acute myocardial infarction and stroke . Usual treatment is to use low molecular weight heparin followed by vitamin K antagonists Other studies have shown that the new oral anticoagulants with or without initial heparin are effective alternatives. The endoxaban is a direct Factor Xa<a href="https://solaci.org/en/2015/06/24/hokusai-vte-endoxaban-shows-solid-results-versus-warfarin-in-venous-thromboembolism/" title="Read more" >...</a>

RE-ALIGN: Dabigatran in mechanical valves. Suspended early due to more bleeding and thrombotic events.

The use of vitamin K antagonists provides excellent protection against thromboembolic complications in patients with mechanical valves, however long-term INR monitoring is needed. Dabigatran is an oral direct thrombin inhibitor which was shown to be effective in patients with atrial fibrillation. Based on these promising results this study was designed to evaluate its use in<a href="https://solaci.org/en/2015/06/24/re-align-dabigatran-in-mechanical-valves-suspended-early-due-to-more-bleeding-and-thrombotic-events/" title="Read more" >...</a>

TASTE: Thrombus aspiration in primary angioplasty failed to show benefits at 30 days

The clinical benefit of thrombus aspiration during angioplasty in patients with ST-segment elevation myocardial infarction is uncertain. The purpose of this work was to test if thrombus aspiration reduces mortality. This was a multicenter, prospective, randomized and controlled study that included patients with ST-segment elevation myocardial infarction within 24 hours of evolution. The catheters used<a href="https://solaci.org/en/2015/06/24/taste-thrombus-aspiration-in-primary-angioplasty-failed-to-show-benefits-at-30-days/" title="Read more" >...</a>

2nd-generation drug-eluting stents, results for “real” patients at two years

Original title: Clinical Outcome Following Stringent Discontinuation of Dual Anti-Platelet Therapy After 12 Months in Real-World Patients Treated With Second-Generation Zotarolimus-Eluting Resolute and Everolimus-Eluting Xience V Stents: Two-Year Follow-up of the Randomized TWENTE Trial. Reference: Keneth T, Hanim S, et al. J Am Coll Cardiol 2013. Article in press.   In recent years there have been new drug-eluting<a href="https://solaci.org/en/2015/06/02/2nd-generation-drug-eluting-stents-results-for-real-patients-at-two-years/" title="Read more" >...</a>

TOTAL Trial: The Best on Manual Thrombectomy in AMI Patients

Original title: Randomized Trial of Primary PCI with or without Routine Manual Thrombectomy. Reference: S.S. Jolly et al. for the TOTAL Investigators. N Engl J Med. 2015 Apr 9;372(15):1389-98. Manual thrombectomy is a routine procedure with ST elevation AMI patients. This common practice proved to reduce mortality in the TAPAS study. However, the TASTE study did not observe<a href="https://solaci.org/en/2015/05/20/total-trial-the-best-on-manual-thrombectomy-in-ami-patients/" title="Read more" >...</a>

ABSORB EXTEND trial: preliminary report of clinical outcomes at 12 months in the first 512 patients

Original title: The ABSORB EXTEND Study: preliminary report of the twelve-month clinical outcomes in the first 512 patients enrolled. Reference: Alexandre Abizaid et al.  EuroIntervention 2015;10:1396-1401. The safety and efficacy of the Absorb Bioresorbable Vascular Scaffold (Absorb BVS) has been previously shown in 131 patients of the ABSORB trial cohorts A and B.  Following this trial, the prospective<a href="https://solaci.org/en/2015/05/19/absorb-extend-trial-preliminary-report-of-clinical-outcomes-at-12-months-in-the-first-512-patients/" title="Read more" >...</a>

Randomized study of bioabsorbable polymer-coated sirolimus-eluting stent: DESSOLVE II protocol results

Original title: Randomised study of a bioabsorbable polymer-coated sirolimus-eluting stent: results of the DESSOLVE II trial. Reference: Wijns W EuroIntervention 2015 Apr 22;10(12):1383-90. Multicenter, randomized study, which enrolled in 26 centers, a total of 184 patients 2:1 (bioabsorbable polymer-coated sirolimus-eluting stent, (SES) [n = 123] versus zotarolimus-eluting stent (ZES) [n = 61]). All patients were evaluated with quantitative<a href="https://solaci.org/en/2015/05/08/randomized-study-of-bioabsorbable-polymer-coated-sirolimus-eluting-stent-dessolve-ii-protocol-results/" title="Read more" >...</a>

Everolimus eluting stent in total occlusions

Original title: Safety and Effectiveness of Everolimus-Eluting Stents in Chronic Total Coronary Occlusion Revascularization Results From the EXPERT CTO (Evaluation of the XIENCE Coronary Stent, Performance, and Technique in Chronic Total Occlusions) Multicenter Trial. Reference: David E. Kandzari et al. J Am Coll Cardiol Intv. 2015, on line before print. The aim of this study was to evaluate<a href="https://solaci.org/en/2015/04/30/everolimus-eluting-stent-in-total-occlusions/" title="Read more" >...</a>

Angioplasty using a drug eluting balloon in the superficial femoral artery

Original title: Drug-Coated Balloon Versus Standard Percutaneous Transluminal Angioplasty for the Treatment of Superficial Femoral and Popliteal Peripheral Artery Disease 12-Month Results From the IN.PACT SFA Randomized Trial. Reference: Gunnar Tepe et al. Circulation. 2015;131:495-502. This interesting study randomly selected 331 patients with intermittent claudication or ischemic rest pain due to stenosis of the superficial femoral artery or<a href="https://solaci.org/en/2015/04/27/angioplasty-using-a-drug-eluting-balloon-in-the-superficial-femoral-artery/" title="Read more" >...</a>