Prospective, multicenter, randomized, double-blind study evaluated intravenous infusion of TRO40303 versus placebo administered immediately before balloon dilation of the culprit artery during primary angioplasty. Infarct size was evaluated using the CK Mb levels and troponin together with magnetic resonance imaging. 163 patients were included; no significant differences were observed in the area under the curve<a href="https://solaci.org/en/2015/06/24/mitocare-tro40303-intravenous-infusion-in-the-context-of-primary-angioplasty/" title="Read more" >...</a>

There are clinics hypothesis that systemic hypothermia (&le;34.9) could reduce infarct size if set before reperfusion. Peritoneal lavage had a well-established safety profile and given the large surface area of the bowel may cause rapid hypothermia reducing infarct size. The aim of this study was to evaluate the safety and efficacy of hypothermia induced by<a href="https://solaci.org/en/2015/06/24/velocity-peritoneal-hypothermia-in-patients-undergoing-primary-angioplasty/" title="Read more" >...</a>

New laboratory tests can detect minimally elevated &nbsp;levels few hours before regarding detection methodologies of previous generations.The hypothesis of this study is that patients with undetectable ultrasensitive troponin ( Conclusion The undetectable ultrasensitive troponin T values in patients with chest pain and no signs of ischemia on the electrocardiogram has an accuracy close to 100%<a href="https://solaci.org/en/2015/06/24/negative-ultrasensitive-troponin-t-values-may-help-discriminate-patients-with-chest-pain-in-the-emergency/" title="Read more" >...</a>

Review: Stable coronary disease remains a scenario where percutaneous coronary intervention, (PCI), has not cleared the edges. In a study conducted in 28 centers in Europe and the United States, a design model was created where all patients enrolled consecutively, (all comers trial in order to avoid selection bias), received an invasive functional assessment using<a href="https://solaci.org/en/2015/06/24/fame-ii-ischemia-guided-ig-percutaneous-coronary-intervention-pci-is-superior-to-medical-treatment/" title="Read more" >...</a>

Background: Octogenarian patients represent an increasingly growing population. In addition, this age group has a higher proportion of co-morbidities with more extensive and complex coronary disease. However, they have often been excluded from major studies, whose average age is usually 60 years. Despite having a more complex coronary anatomy, the role of pharmacological stent (DES)<a href="https://solaci.org/en/2015/06/24/xima-randomized-prospective-study-comparing-everolimus-eluting-stents-versus-conventional-stent-implantation-in-octogenarians/" title="Read more" >...</a>

Background: The ADAPT-DES registry showed a strong correlation between hypo-responders to clopidogrel and the likelihood of stent thrombosis at 30 days, while the impact of aspirin response has not been evaluated so far. This presentation focuses on the aspirin response impact in the clinical course of one year. Methods and Results: A total of 8,583<a href="https://solaci.org/en/2015/06/24/adapt-des-results-at-1-year-of-the-clinical-impact-of-hypo-responders-to-aspirin-and-clopidogrel/" title="Read more" >...</a>

The trial included 1,900 patients followed for at least 2 years, (mean 3.8 years), randomized 1:1 to pharmacological angioplasty stents, (sirolimus or paclitaxel at surgeon discretion), or CABG. We excluded acute coronary syndromes and left coronary trunk injury. The primary endpoint was death, myocardial infarction or stroke and the secondary main was the sum of<a href="https://solaci.org/en/2015/06/24/freedom-trial-cabg-versus-angioplasty-treatment-for-diabetic-patients-with-multivessel-disease/" title="Read more" >...</a>

High levels of HDL are known to exert a protective effect. In previous studies, dalcetrapib administration increased HDL 30% from baseline. The objective was to test dalcetrapib in the context of acute coronary syndrome (ACS). 15,871 ACS patients were randomized to receive dalcetrapib or placebo. Primary end point was cardiac death, myocardial infarction, ictus, new<a href="https://solaci.org/en/2015/06/24/dalcetrapib-dalcetrabib-for-the-treatment-of-acs/" title="Read more" >...</a>

The relative benefits and risks of off-pump coronary artery bypass grafting (CABG) as compared with the use of CBP are not clearly defined. The CORONARY trial in 79 centers randomized 4,752 patients in whom CABG was planned with or without CBP. There was no significant difference in the primary end point which was a composite<a href="https://solaci.org/en/2015/06/24/cabg-off-pump-same-results-at-one-year-pump-surgery/" title="Read more" >...</a>

Routine manual vacuum in patients with acute coronary syndrome and ST-segment elevation improves myocardial perfusion according to non-invasive parameters. Invasive assessment of microcirculation has not been adequately studied in this group of patients. The objective of this study was to compare the effect of manual thromboaspiration in perfusion according to the microcirculation resistance index (MRI).<a href="https://solaci.org/en/2015/06/24/pata-stemi-thromboaspiration-correlates-with-a-lower-index-of-microcirculatory-resistance/" title="Read more" >...</a>