stents

COMPARE II: A randomized prospective study compared the permanent polymer everolimus-eluting stent with a biodegradable polymer biolimus coated stent.

Randomized prospective study comparing the everolimus-eluting polymer-coated stent versus a biodegradable polymer with biolimus coated stent.&nbsp; While the use of first generation DES effectively reduces restenosis and reintervention rates, several meta-analyzes have shown a higher rate of late events of thrombotic origin associated with inflammatory phenomena and delayed reendothelialization at the site of implantation compared<a href="https://solaci.org/en/2015/06/24/compare-ii-a-randomized-prospective-study-compared-the-permanent-polymer-everolimus-eluting-stent-with-a-biodegradable-polymer-biolimus-coated-stent/" title="Read more" >...</a>

COMFORTABLE AMI: A randomized trial comparing a coated stent with biodegradable biolimus polymer (Biomatrix) with an uncoated stent (Gazelle) in patients with AMI with ST segment elevation.

Randomized trial (n = 1161 patients in 16 centers) comparing a coated stent with biodegradable biolimus polymer (Biomatrix) versus uncoated stent (Gazelle) in patients with AMI with ST segment elevation. While there is no doubt about the effectiveness of first generation SF to reduce the rate of reoperations compared with non-drug eluting stents, there is<a href="https://solaci.org/en/2015/06/24/comfortable-ami-a-randomized-trial-comparing-a-coated-stent-with-biodegradable-biolimus-polymer-biomatrix-with-an-uncoated-stent-gazelle-in-patients-with-ami-with-st-segment-elevation/" title="Read more" >...</a>

ISAR-DESIRE 3: A paclitaxel eluting balloon versus Taxus in the treatment of eluting stent restenosis.

Fundamentals. Background: Although we&#8217;ve had more than a decade of experience with implanting drug-eluting stents, (DES), the best treatment for restenosis on these devices remains unknown. The drug-eluting balloons are a promising alternative which avoid the possibility of a new layer of metal on the restenotic injury. This study compared the performance of these balls<a href="https://solaci.org/en/2015/06/24/isar-desire-3-a-paclitaxel-eluting-balloon-versus-taxus-in-the-treatment-of-eluting-stent-restenosis/" title="Read more" >...</a>

ETAP: Endovascular treatment of atherosclerotic popliteal artery lesions: a prospective, multi-center, randomized study.

Introduction: The popliteal artery is a vessel considered unfavorable for the implantation of a stent due to the forces exerted in the popliteal fossa during limb flexion, which could fracture the stent antlers and compromise the outcome of the procedure at long-term. So far, stents used in popliteal lesions have not been compared with balloon<a href="https://solaci.org/en/2015/06/24/etap-endovascular-treatment-of-atherosclerotic-popliteal-artery-lesions-a-prospective-multi-center-randomized-study/" title="Read more" >...</a>

FREEDOM trial: CABG versus angioplasty treatment for diabetic patients with multivessel disease

The trial included 1,900 patients followed for at least 2 years, (mean 3.8 years), randomized 1:1 to pharmacological angioplasty stents, (sirolimus or paclitaxel at surgeon discretion), or CABG. We excluded acute coronary syndromes and left coronary trunk injury. The primary endpoint was death, myocardial infarction or stroke and the secondary main was the sum of<a href="https://solaci.org/en/2015/06/24/freedom-trial-cabg-versus-angioplasty-treatment-for-diabetic-patients-with-multivessel-disease/" title="Read more" >...</a>

NEXT trial looked at a non-inferiority degradable polymer stent versus a second-generation permanent polymer stent.

Previous studies of non-inferiority (SORT-OUT III and V) compared the biodegradable polymer biolimus-eluting stent (BES) with permanent polymer stent and sirolimus-eluting stent (SES) or everolimus-eluting stent (EES), showing no differences, although the data is still contradictory. The aim of this study was to evaluate whether the recently approved BES is not inferior to EES in<a href="https://solaci.org/en/2015/06/24/next-trial-looked-at-a-non-inferiority-degradable-polymer-stent-versus-a-second-generation-permanent-polymer-stent/" title="Read more" >...</a>

DKCRUSH-III: Crushing versus Culotte technique for left main coronary artery

Angioplasty of the unprotected distal left main coronary artery with 2 stents presents the less favorable results in the segment. The double kissing (DK) technique and Culotte technique have been reported as effective for the treatment of bifurcation lesions, however this has never been tested for left main coronary artery.&nbsp; The DKCRUSH-III study investigated the<a href="https://solaci.org/en/2015/06/24/dkcrush-iii-crushing-versus-culotte-technique-for-left-main-coronary-artery/" title="Read more" >...</a>

RENAL DES: reduction of restenosis in patients with kidney failure

Coronary angioplasty in patients with kidney failure is associated with an increased occurrence of events. This study compared the efficacy of preventing clinical restenosis using an everolimus-eluting stent versus a conventional stent, both implanted in the same patient with lesions in more than one vessel and suffering from kidney failure. The primary endpoint was target<a href="https://solaci.org/en/2015/06/24/renal-des-reduction-of-restenosis-in-patients-with-kidney-failure/" title="Read more" >...</a>

IN-PACT CORO: OCT validation of drug-eluting balloons

Drug-eluting balloons could reduce intimal hyperplasia detected by OCT in intmerventions with conventional stents. 30 patients were randomized into 3 groups: 10 patients received conventional stents, 10 patients received a drug-eluting balloon prior to the conventional stent, and 10 patients receive a drug-eluting balloon after the conventional stent. We performed angiographic and OCT follow-up at<a href="https://solaci.org/en/2015/06/24/in-pact-coro-oct-validation-of-drug-eluting-balloons/" title="Read more" >...</a>

J- REVERSE: sirolimus-eluting vs. everolimus-eluting stent in bifurcation lesions

Asymmetrical expansion of the stent produces an uneven neointimal growth and increases the risk of thrombosis. The study was divided into two parts: the first one aimed at comparing, in the acute phase and the medium term, the result of provisional bifurcation stenting technique with sirolimus-eluting stent vs everolimus-eluting stent (both guided by IVUS); the<a href="https://solaci.org/en/2015/06/24/j-reverse-sirolimus-eluting-vs-everolimus-eluting-stent-in-bifurcation-lesions/" title="Read more" >...</a>

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