revascularization

MASS COMM: Elective angioplasty can be performed in hospital with or without emergency surgical support.

Increasingly, the frequent performances of elective angioplasties are in hospitals that do not have a cardiac surgery team. The occurrence for the need of emergency surgery varies from 0.1 to 0.4% in the contemporary age. There is an ongoing debate on health policy about whether to perform elective coronary angioplasty at hospitals without cardiac surgery<a href="https://solaci.org/en/2015/06/24/mass-comm-elective-angioplasty-can-be-performed-in-hospital-with-or-without-emergency-surgical-support/" title="Read more" >...</a>

CABG off-pump, same results at one year-pump surgery.

The relative benefits and risks of off-pump coronary artery bypass grafting (CABG) as compared with the use of CBP are not clearly defined. The CORONARY trial in 79 centers randomized 4,752 patients in whom CABG was planned with or without CBP. There was no significant difference in the primary end point which was a composite<a href="https://solaci.org/en/2015/06/24/cabg-off-pump-same-results-at-one-year-pump-surgery/" title="Read more" >...</a>

GOPCABE: similar results for in-pump or off-pump surgery in elderly patients

Background: There is much debate about a possible benefit of coronary artery bypass grafting (CABG) without cardiopulmonary bypass (CPB) compared with on-pump surgery. However, a randomized study could not confirm this benefit. The objective of these studies was to compare the MACCE, (death, MI, stroke, revascularization repeated and a new dialysis), of surgical revascularization with<a href="https://solaci.org/en/2015/06/24/gopcabe-similar-results-for-in-pump-or-off-pump-surgery-in-elderly-patients/" title="Read more" >...</a>

NEXT trial looked at a non-inferiority degradable polymer stent versus a second-generation permanent polymer stent.

Previous studies of non-inferiority (SORT-OUT III and V) compared the biodegradable polymer biolimus-eluting stent (BES) with permanent polymer stent and sirolimus-eluting stent (SES) or everolimus-eluting stent (EES), showing no differences, although the data is still contradictory. The aim of this study was to evaluate whether the recently approved BES is not inferior to EES in<a href="https://solaci.org/en/2015/06/24/next-trial-looked-at-a-non-inferiority-degradable-polymer-stent-versus-a-second-generation-permanent-polymer-stent/" title="Read more" >...</a>

DKCRUSH-III: Crushing versus Culotte technique for left main coronary artery

Angioplasty of the unprotected distal left main coronary artery with 2 stents presents the less favorable results in the segment. The double kissing (DK) technique and Culotte technique have been reported as effective for the treatment of bifurcation lesions, however this has never been tested for left main coronary artery.&nbsp; The DKCRUSH-III study investigated the<a href="https://solaci.org/en/2015/06/24/dkcrush-iii-crushing-versus-culotte-technique-for-left-main-coronary-artery/" title="Read more" >...</a>

THRIVE: Niacin/laropiprant extended release showed no significant cardiovascular benefit.

The THRIVE study, (also known as HPS2-THRIVE), was a multicenter clinical trial designed to test the hypothesis that the increase in HDL, (using ER niacin/laropiprant), could prevent vascular events in a high risk population already receiving statin standard therapy. Between April 2007 and July 2010 a total of 25,673 randomized patients in China, the UK<a href="https://solaci.org/en/2015/06/24/thrive-niacin-laropiprant-extended-release-showed-no-significant-cardiovascular-benefit/" title="Read more" >...</a>

IN-PACT CORO: OCT validation of drug-eluting balloons

Drug-eluting balloons could reduce intimal hyperplasia detected by OCT in intmerventions with conventional stents. 30 patients were randomized into 3 groups: 10 patients received conventional stents, 10 patients received a drug-eluting balloon prior to the conventional stent, and 10 patients receive a drug-eluting balloon after the conventional stent. We performed angiographic and OCT follow-up at<a href="https://solaci.org/en/2015/06/24/in-pact-coro-oct-validation-of-drug-eluting-balloons/" title="Read more" >...</a>

RENAL DES: reduction of restenosis in patients with kidney failure

Coronary angioplasty in patients with kidney failure is associated with an increased occurrence of events. This study compared the efficacy of preventing clinical restenosis using an everolimus-eluting stent versus a conventional stent, both implanted in the same patient with lesions in more than one vessel and suffering from kidney failure. The primary endpoint was target<a href="https://solaci.org/en/2015/06/24/renal-des-reduction-of-restenosis-in-patients-with-kidney-failure/" title="Read more" >...</a>

ORBIT II: new atherectomy device

The objective of the study was to test the use of a new atherectomy device to prepare severely calcified lesions. It was an observational, prospective, multicenter study that included 443 patients from 49 sites with a 30-day follow-up. The lesion was classified as severely calcified, as fluoroscopy showed the presence of calcium on both sides<a href="https://solaci.org/en/2015/06/24/orbit-ii-new-atherectomy-device/" title="Read more" >...</a>

J- REVERSE: sirolimus-eluting vs. everolimus-eluting stent in bifurcation lesions

Asymmetrical expansion of the stent produces an uneven neointimal growth and increases the risk of thrombosis. The study was divided into two parts: the first one aimed at comparing, in the acute phase and the medium term, the result of provisional bifurcation stenting technique with sirolimus-eluting stent vs everolimus-eluting stent (both guided by IVUS); the<a href="https://solaci.org/en/2015/06/24/j-reverse-sirolimus-eluting-vs-everolimus-eluting-stent-in-bifurcation-lesions/" title="Read more" >...</a>

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