Original title: Invasive Evaluation of Patients with Angina in the Absence of Obstructive Coronary Artery Disease. Reference: Bong-Ki Lee et al.Circulation published online before print February 20, 2015.

More than 20% of patients presenting to the cath lab with angina symptoms have no angiographic evidence of coronary artery disease (CAD). Despite a “normal” angiogram, these patients have persistent symptoms, recurrent hospitalizations, poor functional class, cardiovascular events and, worst of all, no clear diagnosis.

In 139 patients with angina in the absence of CAD (