The incidence of asymptomatic pericardial effusion after cardiac surgery is high. The aim of this study was to evaluate whether colchicine would be able to reduce the volume of postoperative pericardial effusion. This multicenter, double-blind, placebo-controlled study, randomized 197 patients with high risk of cardiac tamponade determined by the presence of persistent pericardial effusion from...
POISE -2: Aspirin before a noncardiac surgery does not reduce the risk of death or myocardial infarction and increased bleeding.
There is great variability in the perioperative administration of aspirin (ASA) in patients undergoing noncardiac surgery, both those who had been receiving and those who not. This work included 10010 patients who planned to undergo noncardiac surgery and were randomized to aspirin versus placebo and clonidine versus placebo. Stratified according to whether they were receiving...
SIRS Trial: Methylprednisolone does not decrease mortality and increase the risk of stroke in patients undergoing cardiac surgery
Cardiac surgery with cardiopulmonary bypass results in an inflammatory response of the body that is usually associated with adverse outcome. The preventive use of corticosteroids attenuates this response although the benefit is not documented.7507 patients with a planned cardiac surgery were randomizedto methylprednisolone or placebo with the primary objective of assessing the mortality at 30...
POISE -2: Clonidine does not reduce the risk of perioperative death or myocardial infarction in patients undergoing noncardiac surgery
There is some evidence that clonidine administered in small doses for short periods of time prior to noncardiac surgery would be able to prevent cardiac events.This study randomized 10010 patients over 45 years in 135 centers in 23 countries to clonidine or placebo. The primary end point of the study was the rate of death...
Non-cardiac surgery and coronary DES
Ajay Kirtane 2011-08-04
Interruption of antiplatelet therapy for non-cardiac surgery
Ajay Kirtane 2011-08-03
Non-cardiac surgery and coronary DES
Ajay Kirtan 2011-08-04
PRAGUE 14: Anti-thrombotic therapy before non-cardiac surgery may be associated with a higher incidence of bleeding.
The majority of coronary patients are under anti-thrombotic therapy and its interruption may increase cardiovascular risk, while on the other hand, continuation during a surgical procedure may increase the risk of bleeding. This study, which included 1211 patients who underwent non-cardiac surgery, compared the interruption of anti-thrombotic therapy at least 7 days prior vs continuing...
Frequency, indication and evolution of emergency cardiac surgery during TAVI
Original Title: Emergent cardiac surgery during transcatheter aortic valve implantation (TAVI): insight the Edwards SAPIENS Aortic Bioprosthesis Outcome (SOURCE) registry. Reference: Holger Eggerbrecht, et al. EuroIntervention 2014;10:975-81 SOURCE register data from patients receiving transcatheter aortic valve implantation with the Edwards Sapiens valve, were analyzed; out of 2307 patients, 27 (1.2%) required emergency cardiac surgery (ECS). Valve stenosis was...
Noncardiac surgery is safe after 6 months after implantation of a DES
Original title: Risk of major adverse cardiac events following noncardiac surgery in patients with coronary stents. Reference: Hawn MT et al. JAMA 2013;DOI:10.1001 In the patients who underwent non cardiac surgery and had coronary angioplasty with stent history within 2 years there was not increased in major cardiac events (MACE ) with the exception of those who were...