The original TWILIGHT findings in more than 9000 patients who underwent angioplasty were presented last year at TCT and showed a 3.1% absolute risk reduction in BARC 2, 3, or 5 bleeding with no increase in death, infarction, or stroke in patients who received ticagrelor and placebo compared with patients who received ticagrelor and aspirin. All patients<a href="https://solaci.org/en/2020/04/02/virtual-acc-2020-twilight-complex-ticagrelor-monotherapy-in-the-most-dangerous-angioplasties/" title="Read more" >...</a>
Virtual ACC 2020 | POPULAR TAVR: Post TAVR Anticoagulation without Clopidogrel?
In patients undergoing transcatheter aortic valve replacement (TAVR) that also required anticoagulation for another indication (mostly atrial fibrillation), the incidence of major bleeding between month 1 and 12 was lower in those receiving only anticoagulation instead of anticoagulation + clopidogrel. The present study presented as part of the scientific sessions at the virtual ACC 2020,<a href="https://solaci.org/en/2020/04/02/virtual-acc-2020-popular-tavr-post-tavr-anticoagulation-without-clopidogrel/" title="Read more" >...</a>
Virtual ACC 2020 | PARTNER 3: TAVR vs CABG in Low Risk at 2 Years
The 2-year outcomes in patients with severe aortic stenosis and low surgical risk continue to show a numerical benefit in favor of transcatheter aortic valve replacement (TAVR) vs. surgical replacement (CABG) for the primary end point of death, stroke or repeat hospitalization for cardiovascular reasons. However, the initially higher advantage of TAVR has been narrowing<a href="https://solaci.org/en/2020/04/02/virtual-acc-2020-partner-3-tavr-vs-cabg-in-low-risk-at-2-years/" title="Read more" >...</a>
Virtual ACC 2020 | COAPT: Better Quality of Life Translates into Harder End-Points
After transcatheter mitral valve repair with MitraClip, the COAPT patients saw improved quality of life, better survival rate and fewer hospitalizations for cardiac failure at long term follow-up.&nbsp; Improved quality of life had already been presented, exactly one year ago at the ACC 2019. In that occasion, it was established that the MitraClip reduces symptoms<a href="https://solaci.org/en/2020/03/25/virtual-acc-2020-coapt-better-quality-of-life-translates-into-harder-end-points/" title="Read more" >...</a>
Virtual ACC 2020 | Conscious Sedation in TAVR
According to the TVT Registry, patients who undergo transcatheter aortic valve replacement (TAVR) with conscious sedation have better outcomes, including lower mortality rates. A minimalist strategy always (sooner or later) proves to be superior across our whole range of procedures, from a simple diagnostic study with local anesthesia and a 4-Fr transradial access, to a<a href="https://solaci.org/en/2020/03/25/virtual-acc-2020-conscious-sedation-in-tavr/" title="Read more" >...</a>
Virtual ACC 2020 | Myocardial Ischemia Induced by Sudden Mental Stress
Myocardial ischemia induced by sudden mental stress is associated with bad prognosis, especially in patients with a history of acute myocardial infarction according to this new study. This study, called MIMS-2, was meant to be presented at ACC 2020 together with the World Congress of Cardiology in Chicago, which was shut down because of the<a href="https://solaci.org/en/2020/03/25/virtual-acc-2020-myocardial-ischemia-induced-by-sudden-mental-stress/" title="Read more" >...</a>
Virtual ACC 2020 | Statins Could Also Protect Against Chemotherapy Cardiotoxicity
This retrospective study has shown a reduction in hospitalization for cardiac failure in patients who were already using statins receiving anthracycline and trastuzumab in the context of breast cancer. The study was to be presented during the ACC 2020 scientific sessions together with the World Congress of Cardiology. However, it had to be called off<a href="https://solaci.org/en/2020/03/23/virtual-acc-2020-statins-could-also-protect-against-chemotherapy-cardiotoxicity/" title="Read more" >...</a>
TAVR in Extremely Large Annuli: Different Patients Might Need Different Prostheses
Nearly all prostheses for transcatheter aortic valve replacement (TAVR) commercially available at present are adequate for most patients. However, there are certain subgroups, relatively small, that could benefit from a particular one. Yesterday we went over the best suited for small annuli, which turned out to be the self-expandable in general and the Evolut PRO<a href="https://solaci.org/en/2020/03/20/tavr-in-extremely-large-annuli-different-patients-might-need-different-prostheses/" title="Read more" >...</a>
Europe Advances the Transcaval Approach for TAVR
The transfemoral access is clearly the preferred approach to transcatheter aortic valve replacement (TAVR), followed by the trans-axillary or trans-subclavian. Despite the alternatives, some patients are still ineligible. This study recently published in EuroIntervention reports initial experiences in Europe with the transfemoral transcaval approach. It included 50 patients from 5 centers assessed according to the<a href="https://solaci.org/en/2020/03/17/europe-advances-the-transcaval-approach-for-tavr/" title="Read more" >...</a>
Another Scandal in Evidence-Based Medicine: Ambulatory BP Monitoring Questioned?
Apparently, the scandal surrounding the EXCEL trial kicked the hornet’s nest as far as evidence-based medicine is concerned. This time, the stars were the actual authors of an article published in the prestigious New England Journal of Medicine (NEJM): the investigators retracted their paper due to issues in data analysis. The aforementioned work was originally<a href="https://solaci.org/en/2020/03/11/another-scandal-in-evidence-based-medicine-ambulatory-bp-monitoring-questioned/" title="Read more" >...</a>