Though the benefit of FFR (fractional flow reserve) over angiography is statistically important only over the first 2 years, this pattern is maintained at long term according to FAME 5 year follow up, presented at the ECS and simultaneously published in The Lancet. Between the second and fifth year, the number of patients at risk...
Long lesions (≥ 15 cm), total occlusions, and in-stent restenosis represent a unique treatment challenge in peripheral vascular disease. IN.PACT Global study is a prospective, multicenter, single arm designed to evaluate the safety and efficacy of IN.PACT® ADMIRAL® drug eluting balloon for the treatment of superficial femoral and popliteal arteries in a real-world population. A...
The European guidelines recommend revascularization within 24 hours in high-risk patients with No ST segment elevation myocardial infarction. It is unclear whether these patients would benefit from an immediate strategy. This randomized, open, and controlled study included 250 patients with suspected Non ST segment elevation myocardial infarction. Patients were randomized to early coronary angiography or...
Fundamentos e objetivos: A intervenção coronária percutânea (PCI) primária da artéria culpada pelo infarto agudo do miocárdio com supra de ST (STEMI) é o método de escolha no tratamento deste quadro clínico. O objetivo do presente estudo foi encontrar a gestão ótima dos doentes com STEMI que apresentavam pelo menos mais uma estenose de artéria...
This observational registry compared the results of myocardial revascularization with angioplasty performed using everolimus-eluting stents in patients with multivessel. The primary endpoint of the study was mortality from any cause. Side end points were infarction, stroke, and revascularization. Propensity score was used to compare populations. Between 34819 patients were eligible 9223 patients in each group...
The aim of this study was to compare the usefulness of primary angioplasty only to culprit vessel versus complete revascularization guided by fractional flow reserve (FFR) in patients admitted pursuing an acute myocardial infarction with ST-segment elevation and have multiple injuries vessels. After a successful primary angioplasty to culprit artery, patients were randomized 1:1 to...
This work included 18144 patients from 39 countries that were admitted pursuing an acute coronary syndrome (with or without ST segment elevation) randomized 1: 1 to receive the combination of simvastatin 40 mg / ezetimibe 10 mg (n = 9067) or simvastatin 40 mg alone (n = 9077). Of the total, 88% received a coronary...
The aim of this study was to assess treatment with the new anticoagulant Pegnivacogin and its specific antidote Anivamersen compared with bivalirudin in patients undergoing coronary angioplasty. The Pegnivacogin has an affinity for factor IXa with a longer shelf life to 24 hours and Anivamersen only has an affinity for Pegnivacogin. The combination of these...
The aim of this study was to evaluate the safety and efficacy of long-term Evolocumab, an inhibitor of PCSK9 added to standard therapy versus standard therapy alone. Patients of five works in phase two and seven works in phase three were invited to participate in the extended program. These patients were randomized 2:1 to Evolocumab...
The aim of this study was to evaluate Coronary angiography by multislice CT compared with standard therapy in patients at low or moderate risk with suggestive symptoms of coronary artery disease. 2073 patients were included in each branch with a mean follow up of 1.7 years. CT significantly increased the certainty of the diagnosis of...