acute myocardial infarction

Lower Rates of In-Stent Thrombosis with the New Generation DES

Original title:&nbsp;New-generation drug-eluting stents reduce stent thrombosis and myocardial infarction: a propensity-score-adjusted analysis from the multicenter REAL registry.&nbsp;Reference:&nbsp;Vignali L et al. Cath Cardiovasc Interv. 2014; Epub ahead of print. Compared to the first generation of drug eluting stents (DES), the new generation has a lower long term risk of in-stent thrombosis and acute myocardial infarction<a href="https://solaci.org/en/2014/10/30/lower-rates-of-in-stent-thrombosis-with-the-new-generation-des/" title="Read more" >...</a>

Increased security with bivalirudin than with heparin alone in patients without ST segment.

Original title:&nbsp;Heparin monotherapy or bivalirudin during percutaneous coronary intervention in patients with non-ST-segment elevation acute coronary syndromes or stable ischemic heart disease: results from the Evaluation of Drug-Eluting Stents and Ischemic Events registry.&nbsp;Reference:&nbsp;Bangalore S et al. CircCardiovascInterv. 2014;Epub ahead of print. Bivalirudin compared to unfractionated heparin as monotherapy is associated with a lower risk of<a href="https://solaci.org/en/2014/05/14/increased-security-with-bivalirudin-than-with-heparin-alone-in-patients-without-st-segment/" title="Read more" >...</a>

Blush reduction in a not responsible vessel is a prognostic marker in those receiving angioplasty in the culprit vessel.

Original title:&nbsp;Impact of Nonculprit Vessel Myocardial Perfusion on Outcomes of Patients Undergoing Percutaneos Coronary OIntervention for Acute Coronary S&iacute;ndromes. Analysis From ACUITY Trial.&nbsp;Reference:&nbsp;Alexandra Lansky, et al. JAAC Cardiovascular Intervention 2014,7:266-275 In Non ST elevation Acute Coronary Syndrome (NSTE-ACS) is demonstrated that revascularization of the culprit vessel is beneficial, but strategy it is not yet clear<a href="https://solaci.org/en/2014/05/09/blush-reduction-in-a-not-responsible-vessel-is-a-prognostic-marker-in-those-receiving-angioplasty-in-the-culprit-vessel/" title="Read more" >...</a>

Higher event rate in those with non-ST elevation ACS who received revascularization at PLATO study. Beyond this, ticagrelor reduced mortality.

Original title:&nbsp;Ticagrelor vs. clopidogrel in patients with non-ST-elevation acute coronary syndrome with or without revascularization: results from the PLATO trial.&nbsp;Reference:&nbsp;Lindholm D et al. Eur Heart J. 2014; Epub ahead of print. The PLATO study randomized 18624 patients with ACS to aspirin and ticagrelor (180 mg loading dose followed by 90 mg every 12 hours) versus<a href="https://solaci.org/en/2014/05/07/higher-event-rate-in-those-with-non-st-elevation-acs-who-received-revascularization-at-plato-study-beyond-this-ticagrelor-reduced-mortality/" title="Read more" >...</a>

Deferred Stenting in Primary Angioplasty could reduce No Reflow Risk and Infarct Size.

Original:&nbsp;A Randomized Trial of Deferred Stenting versus Immediate Stenting to Prevent No-or Slow Reflow in Acute ST-Elevation Myocardial Infarction (DEFER-STEMI).&nbsp;Reference:&nbsp;David Carrick et al. J Am Coll Cardiol. 2014. Epub ahead of print. No Reflow physiopathology involves microvascular obstruction secondary to thrombus embolization, spasm or microvascular thrombosis, and happens in approximately 10% of PCI procedures. The<a href="https://solaci.org/en/2014/03/17/deferred-stenting-in-primary-angioplasty-could-reduce-no-reflow-risk-and-infarct-size/" title="Read more" >...</a>

Best results of angioplasty with DES guided by IVUS versus angiography only

Original title:&nbsp;Intravascular Ultrasound-Guided Implantation of Drug-Eluting Stents to Improve Outcome. A Meta-Analysis.&nbsp;Reference:&nbsp;Jae-Sik Jang et al. J Am Coll Cardiol Intv 2014, epub ahead of print. Several previous studies and meta-analysis showed that implantation of conventional stents (BMS) intravascular ultrasound (IVUS) guided may decrease restenosis and clinical events. This information was not yet clear to drug-eluting<a href="https://solaci.org/en/2014/02/26/best-results-of-angioplasty-with-des-guided-by-ivus-versus-angiography-only/" title="Read more" >...</a>

3rd generation zotarolimus-eluting stent non- inferior to everolimus

Original title:&nbsp;Third-generation zotarolimus-eluting and everolimus-eluting stents in all-comer patients requiring a percutaneous coronary intervention (DUTCH PEERS): a randomized, single-blind, multicentre, non-inferiority trial.&nbsp;Reference:&nbsp;Von Birgelen C et al. The Lancet. 2014; Epub ahead of print. In the 3rd generation zotarolimus-eluting stent, platform was modified to increase flexibility and make implant easier in complex lesions. This study was<a href="https://solaci.org/en/2014/02/13/3rd-generation-zotarolimus-eluting-stent-non-inferior-to-everolimus/" title="Read more" >...</a>

Malapposition in drug-eluting stents. Much more common and much less serious than we thought

Original title:&nbsp;Incidences, Predictors, and Clinical Outcomes of Acute and Late Stent Malapposition Detected by Optical Coherence Tomography After Drug-Eluting Stent Implantation&nbsp;Reference:&nbsp;Im E. et al. CircCardiovascInterv. 2014 Jan 14. [Epubahead of print] &nbsp; This paper analyzed the imaging of 351 patients by optical coherence tomography (OCT) who received drug-eluting stents over 356 lesions between 2009 and<a href="https://solaci.org/en/2014/01/28/malapposition-in-drug-eluting-stents-much-more-common-and-much-less-serious-than-we-thought/" title="Read more" >...</a>

Ischemic versus anatomical risk. Is anyone better to help us decide therapeutically?

Original title:&nbsp;Predicting Outcome in the COURAGE Trial. Coronary Anatomy Versus Ischemia.&nbsp;Reference:&nbsp;G. B. John Mancini et al. J Am Coll Cardiol Intv 2013,&nbsp;Article in press. &nbsp; Anatomical risk, ischemic amount or a combination of both, are often factors taken into account for estimating the prognosis or choose a treatment strategy. The COURAGE study (Clinical Outcomes Utilizing<a href="https://solaci.org/en/2014/01/24/ischemic-versus-anatomical-risk-is-anyone-better-to-help-us-decide-therapeutically/" title="Read more" >...</a>

Unprotected trunk in diabetics: angioplasty with good long-term results but more revascularization

Original title:&nbsp;Coronary artery bypass graft versus percutaneous coronary intervention with drug-eluting stent implantation for diabetic patients with unprotected left main coronary artery disease: D-DELTA registry.&nbsp;Reference:&nbsp;Meliga Emanuele, et al. EuroIntervention 2013; 9:803-808 Diabetes increases cardiovascular risk events because of their involvement in diffuse form of the vessels, thereby generating more events and changes in revascularization strategy<a href="https://solaci.org/en/2013/12/12/unprotected-trunk-in-diabetics-angioplasty-with-good-long-term-results-but-more-revascularization/" title="Read more" >...</a>

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