ACC 2019 | SMART-CHOICE: Aspirin Increasingly “Against the Ropes”

This work (presented during the same American College of Cardiology [ACC] 2019 Scientific Session as the STOPDAPT-2 trial) enrolled 2993 patients who underwent angioplasty with current-generation stents Xience, Promus, Synergy, or Orsiro at 33 Korean sites. Patients were randomized to 12 months of dual antiplatelet therapy or dropping aspirin at 3 months.

ACC 2019 | SMART-CHOICE: la aspirina cada vez más “contra las cuerdas”There was no difference between the short- and long-term dual antiplatelet therapy regime regarding the primary combined endpoint (death, infarction, stroke), with rates of 2.9% vs 2.5%. This information was confirmed in an exploratory analysis at 90 days.


Clinical events at 1 year were similar between study groups, with the exception of higher rates of BARC 2-5 bleeding observed in the group receiving aspirin for 12 months (2.0% vs 3.4%; hazard ratio [HR]: 0.36; 95% confidence interval [CI]: 0.36-0.92; p = 0.02).


All prespecified subgroups seemed to consistently derive benefit, although patients who received prasugrel or ticagrelor (as opposed to clopidogrel) tended to do better.

Read also: ACC 2019 | TAVR in Bicuspids is Safe and Feasible in Real World Patients.

This work suggests that P2Y12 inhibitor monotherapy after short conventional dual antiplatelet therapy is a new strategy that seems to balance well ischemic and bleeding risks in patients undergoing angioplasty.


One of the limitations of this study was that 16% of patients randomized to dropping aspirin at 3 months actually continued taking it.

Read also: ACC 2019 | PARTNER 3: Low Risk TAVR vs. Surgery, Fewer Events per Year.

An important detail is that about half the study population (and the STOPDAPT-2 population) underwent a simple angioplasty; in consequence, these results cannot be generalized.


Original title: P2Y12 Inhibitor Monotherapy Versus Dual Antiplatelet Therapy in Patients Undergoing Percutaneous Coronary Intervention: The SMART-CHOICE Randomized, Open-Label, Noninferiority Trial.

Presenter: Hahn J-Y.

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