The incidence of asymptomatic pericardial effusion after cardiac surgery is high. The aim of this study was to evaluate whether colchicine would be able to reduce the volume of postoperative pericardial effusion. This multicenter, double-blind, placebo-controlled study, randomized 197 patients with high risk of cardiac tamponade determined by the presence of persistent pericardial effusion from...

There is great variability in the perioperative administration of aspirin (ASA) in patients undergoing noncardiac surgery, both those who had been receiving and those who not. This work included 10010 patients who planned to undergo noncardiac surgery and were randomized to aspirin versus placebo and clonidine versus placebo. Stratified according to whether they were receiving...

Cardiac surgery with cardiopulmonary bypass results in an inflammatory response of the body that is usually associated with adverse outcome. The preventive use of corticosteroids attenuates this response although the benefit is not documented.7507 patients with a planned cardiac surgery were randomizedto methylprednisolone or placebo with the primary objective of assessing the mortality at 30...

There is some evidence that clonidine administered in small doses for short periods of time prior to noncardiac surgery would be able to prevent cardiac events.This study randomized 10010 patients over 45 years in 135 centers in 23 countries to clonidine or placebo. The primary end point of the study was the rate of death...

Ajay Kirtane 2011-08-04

Ajay Kirtane 2011-08-03

Ajay Kirtan 2011-08-04

The majority of coronary patients are under anti-thrombotic therapy and its interruption may increase cardiovascular risk, while on the other hand, continuation during a surgical procedure may increase the risk of bleeding. This study, which included 1211 patients who underwent non-cardiac surgery, compared the interruption of anti-thrombotic therapy at least 7 days prior vs continuing...